|
KMID : 0390320120220010075
|
|
Chungbuk Medical Journal
2012 Volume.22 No. 1 p.75 ~ p.82
|
|
|
Expreience of Use of Platelet Function Analyzer-100 Closure Times : The evaluation of platelet function according to thrombocytes
|
|
Shin Kyeong-Seob
Son Bo-Ra
|
|
|
Abstract
|
|
|
Purpose: The PFA-100 (platelet function analyzer) is a relatively new tool for the investigation of primary hemostasis. The PFA-100 has potential utility in monitoring antiplatelet therapy (including aspirin) and as a screening tool for investigating possible von Willebrand disease (VWD) and various platelet disorders. We performed this study to reconfirm preanalytical variables on Closure time (CT) in our laboratory. .
Material and Methods: Closure times with the PFA-100 system were determined for the Collagen/ADP (CADP) in 156 patients and the Collagen/Epinephrine (CEPI) cartridges in 119 patients. The reference ranges of CT were 61-110 sec of CADP and 81-192 sec of CEPI. We analyzed preanalytical effects of gender, age, Hct an platelet counts.
Results: Hct levels over 40 year group are significantly lower than younger group in CEPI-CT group (P=0.030). Platelet counts over 40 year group are significantly lower than younger group in CEPI-CT group, especially normal CEPI-CT group (P=0.002 and 0.001, respectively). The gender, age, Hct and platelet counts are not significantly different in CADP-CT group.
Conclusion: We confirmed the preanalytical variables of PFA-CT and recommended the comment for effect of Hct and platelet count in the reporting sheets.
|
|
|
KEYWORD
|
|
|
PFA-100 closure time, Preanalytical variables
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|